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Surgical Vignettes: Lobular Carcinoma In Situ (Important Points)

Ref: Schwartzs 10th ed (http://amzn.to/1q10JSc)
Lobular Carcinoma In Situ
Image Source: Wikipedia
  • Calcifications associated with LCIS typically occur in adjacent tissues. This neighbourhood calcification is a feature that is unique to LCIS and contributes to its diagnosis.
  • The average age at diagnosis is 45 years, which is approximately 15 to 25 years younger than the age at diagnosis for invasive breast cancer
  • Invasive breast cancer develops in 25% to 35% of women with LCIS. 
  • Invasive cancer may develop in either breast, regardless of which breast harbored the initial focus of LCIS, and is detected synchronously with LCIS in 5% of cases. 
  • In women with a history of LCIS, up to 65% of subsequent invasive cancers are ductal, not lobular, in origin. 
  • For these reasons, LCIS is regarded as a marker of increased risk for invasive breast cancer rather than as an anatomic precursor


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