, , , , , ,

Adhesive Band Causing Small Bowel Obstruction

Adhesive Band causing Intestinal Obstrucction
Adhesive Band causing Intestinal Obstrucction

Which protein is responsible for formation of adhesions?
Adhesions are formed by fibrin deposits onto the damaged tissues. The fibrin acts like a glue to seal the injury and builds the fledgling adhesion. In body cavities such as the peritoneal, pericardial and synovial cavities, a family of fibrinolytic enzymes may act to limit the extent of the initial fibrinous adhesion, and may even dissolve it. In many cases however the production or activity of these enzymes are compromised because of injury, and the fibrinous adhesion persists. If this is allowed to happen, tissue repair cells such as macrophages, fibroblasts and blood vessel cells, penetrate into the fibrinous adhesion, and lay down collagen and other matrix substances to form a permanent fibrous adhesion.

What are the types of adhesions?
There are three general types of adhesions: filmy, vascular, and cohesive

What percentage of individuals develop adhesions after surgery?
A study showed that more than 90% of patients develop adhesions following open abdominal surgery and 55–100% of women develop adhesions following pelvic surgery [1].

Does adhesive intestinal obstruction always require surgery?
Simple obstruction secondary to an adhesion is most likely to resolve nonoperatively.

What is the most common cause of small bowel obstruction?
Adhesive obstruction is the most common cause of small bowel obstruction. In the United States, peritoneal adhesions account for over half of the cases of small bowel obstruction.

View the link below for more important points:

[1] Liakakos, T; Thomakos, N; Fine, PM; Dervenis, C; Young, RL (2001). "Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management". Digestive surgery 18 (4): 260–73. doi:10.1159/000050149. PMID 11528133