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Neurosurgery MCQ. 2 : Which of the following is a site of neurogenesis in adults?


1. Subventricular zone 
2. Substantia nigra 
3. Subgranular zone 
4. 1 and 3


Neurogenesis in adults occurs in the subventricular zone lining the ventricles and at the subgranular zone at the dentate gyrus of the hippocampus. 

Neurons and glial cells are produced by multipotent stem cells

Contrary to the long-held belief that neurogenesis tapers off with the end of early postnatal development, the mammalian brain retains the capacity to generate new neurons throughout life. 

Adult neural stem/progenitor cells (NSPCs) are responsible for the generation of new neurons and reside in two main locations in the adult brain: 
  • the subventricular zone (SVZ) lining the lateral ventricles, and 
  • the hippocampal dentate gyrus (DG) 
Gage, 2000)  (Doetsch et al., 1999Bonaguidi et al., 2011)


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